Peptide Nucleic Acids, Morpholinos and Related Antisense by Christopher G. Janson M.D., Matthew J. During M.D., Sc.D.

By Christopher G. Janson M.D., Matthew J. During M.D., Sc.D. (auth.)

This quantity is exclusive to the prevailing literature within the Peptide Nucleic Acid box, in that it makes a speciality of evaluating and contrasting PNA with different on hand oligonucleotide homologues and considers parts within which those biomolecules should be profitably utilized to scientific and diagnostic purposes. half I of the booklet addresses comparative strengths and weaknesses of assorted nucleoside homologues. half II of the publication addresses particular translational or medical functions for PNA and comparable antisense biomolecules. The editors have succeeded in providing a balanced but huge view of the equipment to be had for gene concentrating on and amendment.

Show description

Read or Download Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules PDF

Similar nonfiction_9 books

IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

The data of Th17 cells and different mobilephone populations which secrete IL-17A, and/or IL-22 has multiplied significantly because the ebook of the 1st variation “Th17 Cells: function in irritation and Autoimmune sickness” in 2008. the current quantity has been thoroughly revised with the addition of latest chapters at the IL-17 receptor relations and signaling, and an in-depth evaluate of IL-22 and innate lymphoid cells.

Ciba Foundation Symposium - Breathing: Hering-Breuer Centenary Symposium

Quantity 1 tools and functions of records in medical Trials, quantity 1: innovations, ideas, Trials, and Designs effectively upholds the objectives of the Wiley Encyclopedia of scientific Trials by way of combining either previously-published and newly built contributions written by way of over a hundred best teachers, researchers, and practitioners in a entire, approachable layout.

Around the Tree: Semantic and Metaphysical Issues Concerning Branching and the Open Future

Over the last few years, the tree version of time has been extensively hired to house concerns about the semantics of tensed discourse. the concept that has encouraged its adoption is that the main believable solution to make experience of indeterminism is to conceive of destiny percentages as branches that leave from a standard trunk, constituted through the earlier and the current.

Additional info for Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules

Example text

Brandon LJ, Mohamed AJ, Smith CIE. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of D N A . Nat Biotechnol 1999; 17:784-787. 100. Liang KW, Hoffman EP, H u a n g L. Targeted delivery of plasmid D N A to myogenic cells via transferrin-conjugated peptide nucleic acid. Molecular Therapy 2000; 1:236-243. CHAPTER 2 Modulation of Nucleic Acid Information Processing by PNAs: Potential Use in Anti-Viral Therapeutics Lionel Bastide, Bernard Lebleu and Ian Robbins Introduction Nucleic Acid Information Processing T he transfer of genetic information from one nucleic acid molecule (DNA or RNA) to another (replication, transcription) or to proteins (translation) is a fundamental life process.

T h e age-related accumulation of a mitochondrial D N A control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. Nucleic Acids Res 2000; 28:4350-4355. 76. Myal Y, Blanchard A, Watson P et al. Detection of genetic point mutations by peptide nucleic acid-mediated polymerase chain reaction clamping using paraffin-embedded specimens. Anal Biochem 2000; 285:169-172. 77. Von Wintzingerode F, Landt O , EhrUch A et al. Peptide nucleic acid-mediated PCR clamping as a useftil supplement in the determination of microbial diversity.

Nucleic Acids Res 2 0 0 1 ; 29(2):565-572. 39. Tackett AJ, Morris P D , Dennis R et al. Unwinding of unnatural substrates by a D N A helicase. Biochemistry 2 0 0 1 ; 40(2):543-548. 40. Died G, Corradini R, Sforza S et al. Inhibition of RNA polymerase III elongation by a TIO peptide nucleic acid. J Biol Chem 2001; 276(8):5720-5725. 4 1 . Bentin T, Nielsen PE. Enhanced peptide nucleic acid binding to supercoiled DNA: Possible implications for D N A breathing dynamics. Biochemistry 1996; 35(27):8863-8869.

Download PDF sample

Rated 4.02 of 5 – based on 13 votes