By Paul Flecknell, Avril Waterman-Pearson BVSc PhD FRCVS DVA DiplECVA
Finally a truly strong sensible e-book on easy methods to deal with discomfort. It in actual fact summarises the facts that animals think soreness after which - this the easiest bit - turns the technology into actual support for front-line training vets.
A must-have for all vets all over
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Additional info for Pain Management in Animals
Recent work in humans has indicated a. role for COX-2 inhibition in the therapy of colonic cancer. This may represent a new role for NSAID use in the future. Pharmacokinetics NSAIDs are generally well absorbed after oral, subcutaneous and intramuscular injection. g. phenylbutazone). The NSAIDs are all highly protein bound in plasma, more than 99% in some cases, and this can limit the passage of drug from plasma into the interstitial fluid. Most NSAIDs have low volumes of distribution (typically 200-300ml/kg), although tolfenamic acid has a much greater volume of distribution in dogs.
Approx. 8 h in the dog and approx. 24 h in sheep. It is well absorbed from the GIT and is suitable for once daily administration, although frequently the daily dose is divided in two treatments. Carprofen appears to have a wide safety margin for gastric ulceration, which may reflect its poor activity as a COX inhibitor, and at therapeutic doses it is chondroprotective (in vitro studies). A report of hepatocellular toxicosis potentially associated with carprofen administration was recently made (MacPhail et al 1998).
Horses show increased locomotor activity when given opioid drugs, and other behaviours such as compulsive eating behaviour and agitation (Combie et al 1981, Nolan et al 1994). Many of these effects are reduced when opioids are used in combination with the tranquilliser acepromazine or the alpha-2 adrenoceptor agonist sedatives such as xylazine (Nolan & Hall 1984). Tolerance and dependence Tolerance can be defined as the decrease in effectiveness of a drug after repeated administration. It is a complex phenomenon with important therapeutic implications where drugs are to be administered over a prolonged period of time.