Nucleic Acids and Molecular Biology by E. Paleček (auth.), Prof. Dr. Fritz Eckstein, Prof. Dr.

By E. Paleček (auth.), Prof. Dr. Fritz Eckstein, Prof. Dr. David M. J. Lilley (eds.)

Molecular biology is without doubt one of the such a lot speedily constructing and while most enjoyable disciplines. the main to molecular biology lies within the knowing of nucleic acids - their constitution, functionality, and interplay with proteins.
Nucleic Acids and Molecular Biology retains scientists knowledgeable of the explosively growing to be info and complies with the nice curiosity during this box by way of delivering a persisted excessive average of assessment. a considerable a part of this quantity has been dedicated to the research of other features of nucleic acid-protein-interactions together with RNA-protein-interaction.

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Pardi, pers. ); this results in part from the relatively high stability of the G-A base pair in nucleic acids. We reasoned that disulfide cross-linking could be used to trap the stem-loop form and thereby prevent its interconversion with the duplex form. Indeed, when the 8mer containing two thiol-tethered C residues was reduced and allowed to oxidize 35 The Convertible Nucleoside Approach ~C I ~ (+~ NJLN~ DMTO~ oI I NCEIO ...... p, ~ ~<:. 0 C ~N I NAo DMTO~ l o I NCEIO ...... p, '\ OTBDMS -------- N(iPr}2 CI-$-U phosphoramldlte Fig.

1992). Automated DNA synthesis methods were used to synthesize an oligonucleotide capable of forming a stem-loop structure with a N 3 -benzoylmercaptoethyl-2'-deoxythymidine at each end (Fig. 11). E. L. Verdine AG G A ricin cleavage site ~ GC CG 5' 3' stem-loop 5'-CGGAGACG-3' 5'-CGGAGACG-3' 3'-GCAGAGGC-5' duplex Fig. 10. Alternative self-associated forms of an RNA 8mer contaInIng the GAGA sequence: stem-loop, which contains the GAGA-loop ricin cleavage motif; and duplex, which contains G-A base pairs.

The situation is less favorable in the case of DNA. The presence and the concentration of the molecules in the thin region of the film are rarely predictable. It may change from one specimen to the other and varies from place to place in the thin film. Worse than that, there are specimens in which a majority of the DNA molecules adsorb to the surface instead of being suspended in all the available volume of the solution. In general, these effects are influenced by proteins and other molecules of the solution.

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