Natural Compounds as Drugs, Volume I (Progress in Drug by Frank Petersen, René Amstutz

By Frank Petersen, René Amstutz

Using drug components derived from crops, fungi, micro organism, and marine organisms has a protracted culture in drugs. including their derivatives, and artificial compounds deduced from average product precursors, they characterize an incredible a part of latest pharmaceutical industry. in the speedy constructing self-discipline of molecular biology, usual items additionally play an incredible position as device compounds in pathway screening and validation of aim identity options. they supply cutting edge possibilities in drug discovery, resulting in a close knowing of organic pathways and revealing the services of concerned enzymes or receptors. This e-book highlights new traits and facets in common items study. It discusses the biodiversity-driven techniques that are now of eminent significance in average items learn, addressing the query why traditional items show this type of advanced chemical details, what makes them frequently specified and what their features are. sensible questions similar to offer of average components and creation optimization options also are coated.

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Additional resources for Natural Compounds as Drugs, Volume I (Progress in Drug Research) (Progress in Drug Research)

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Following the success of these agents, other pharmaceutical companies used the information from mevastatin (3) and lovastatin (69) (effectively 20 Mother nature’s gifts to diseases of man HO HO CO2O NaDPH CO2- HO OH H+ NaDPH H+ CO2- HO O Mevalonic Acid Synthesis 68 HO CO2H OH HO O O O O O O O O OH SCoA SCoA HO O O O H lovastatin (69) mevastatin (3) HO F N O CO2H OH O O H H H HN HO simvastatin (70) atorvastatin (4) pravastatin (71) the NP’s ‘warhead plus a lipophilic attachment’) to develop a series of molecules, some of which have been approved for use.

Drugs 62: 2221–2234 Kahne D, Leimkuhler C, Lu W, Walsh C (2005) Glycopeptide and lipoglycopeptide antibiotics. Chem Rev 105: 425–448 Iso Y, Irie T, Iwaki T, Kii M, Sendo Y, Motokawa K, Nishitani Y (1996) Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661. J Antibiot 49: 478–484 Anderson DL (2006) Doripenem. Drugs Today (Barc) 42: 399–404 Sum PE, Lee VJ, Testa RT, Hlavka JJ, Ellestad GA, Bloom JD, Gluzman Y, Tally FP (1994) Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines.

Curr Pharm Des 12: 2623–2630 Altmann K-H (2004) The merger of natural product synthesis and medicinal chemistry: On the chemistry and chemical biology of epothilones. Org Biomol Chem 2: 2137–2152 Bergstralh DT, Ting JP (2006) Microtubule stabilizing agents: Their molecular signaling consequences and the potential for enhancement by drug combination. Cancer Treat Rev 32: 166–179 Höfle G, Bedorf N, Gerth K, Reichenbach H (1993) German Patent No. DE4,138,042 Höfle G, Bedorf N, Steinmetz H, Schomburg D, Gerth K, Reichenbach H (1996) Epothilone A and B – novel 16-membered.

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