By Joanne T. Douglas, David T. Curiel (auth.), Prof. Robert A. Stockley (eds.)
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Additional resources for Molecular Biology of the Lung: Volume II: Asthma and Cancer
3. Transcription Factor Interactions One of the most important concepts to have emerged is that transcription factors may interact with other transcription factors. This then allows crosstalk between different signal transduction pathways at the level of gene expression . Indeed, it is the interaction of transcription factors that may give them different properties in different cell types, because the presence of other transcription factors will profoundly influence the effect exerted by a particular factor on gene expression.
With the Human Genome Project progressing rapidly, it is easy to foresee combined linkage and sequence data allowing the rapid identification of genes at a peak of linkage. Gene identification is only the start of the long path to drug therapy, because there is still a formidable amount of work to do to move from each gene sequence to the clarification of its role in the development of asthma. 6. Conclusions The genetic basis for asthma is gradually becoming more certain; the methodological tools for finding genetic linkage and association are now established, and it is likely that all the important genes and their variants will be found in the next 10 years.
Association of HLA antigens and Parthenium rhinitis. Clin ExpAllergy 20: 555-560 39 Fischer GF, Pickl WF, Fae I, Ebner C, Ferreira F, Breiteneder H, Vikoukal E, Scheiner 0, Kraft D (1992) Association between IgE response against Bet v I, the major allergen of birch pollen, and HLA-DRB alleles. J. M. Cookson 40 Marsh DG, FreidhoffLR, Ehrlich-Kautzky E, Bias WB, Roebber M (1987) Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans.