Molecular Biology and Physiology of Insulin and Insulin-Like by J. S. Sussenbach, P. H. Steenbergh, E. Jansen, P.

By J. S. Sussenbach, P. H. Steenbergh, E. Jansen, P. Holthuizen, D. Meinsma (auth.), Mohan K. Raizada, Derek LeRoith (eds.)

This quantity addresses a primary puzzle in biology and medication, particularly, how does tissue enhance, fix and change itself. the reply seems to lie in development elements and their law. To thrive and live on we want development elements and this ebook concentrates on components which are concerning development hormone. progress hormone doesn't act at once on all tissues, yet mediates a lot of its activities during the unencumber of insulin-like progress elements from the liver. the expansion elements have been initially referred to as somatomedins by way of McConaghey and Sledge (1), who came upon that they mediated growth-like results of progress hormone. besides the fact that, the criteria have been purified at the foundation in their insulinomimetic activities on fats and muscle and it's their dating to the insulin kin of pep tides that now provides them their identify (2,3) of insulin-like development components (IGFs). They mediate the activities of. development hormone at the proteoglycan synthesis of cartilage and convey mitogenic results in fibroblast cultures.

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Proc. Natl. Acad. Sci. USA, 75:180. , 1989, Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by man nose 6-phosphate, insulin like growth factors and epidermal growth factor. , 8:686. , and Czech, M. , 1985, Mechanism of insulin action on membrane protein recycling: a selective decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane. Proc. Natl. Acad. Sci. USA, 82:7314. Czech, M. , 1989, Signal transmission by the insulin-like growth factors.

2-kb transcripts were detected with the exon 4 probe. The translational status of the different IGF-II mRNAs was determined by isolation of polysomes from detergent-lysed IN 157 cells. 2-kb transcript co-migrated with the monosome fraction. 8-kb transcript was associated with membrane-bound and not "free" polysomes, whereas the other transcripts were free in the cytoplasm. 2-kb transcripts was not sensitive to EDTA indicating that they are not associated with ribosomes or their subunits, but are present in stable cytoplasmic particles not directly engaged in protein synthesis.

Brown, A. , Graham, D. , Rechler, M. , and Bruni, C. , 1986, Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. J. BioI. , 261 :138. , Ellis Horwood Limited, pp. 176-210. , 1986, Protein kinase activity of the insulin receptor. Biochem. , 235:1. , Haselbacher, G. , Humbel, R. , 1985, Two types of receptor for insulin-like growth factors in mammalian brain. , 4:3407. , Tam, A. , Dull, T. , Cavanee, W. , 1987, Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene.

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