By Margaret M. McCarthy (auth.), Margaret M. McCarthy (eds.)
When first brought, antisense oligonucleotides have been hailed because the lengthy awaited magic bullet that might supply an remarkable point of specificity in controlling gene expression. Following this preliminary enthusiasm, antisense oligonucleotides were maligned as nonspecific, poisonous, and basically dead. despite the fact that, program of antisense oligonucleotide know-how within the apprehensive process stands except using this system in peripheral platforms, principally due to its huge, immense good fortune. The resource of this good fortune continues to be an issue of a few controversy.
Modulating Gene Expression by way of Antisense Oligonucleotides to UnderstandNeural Functioning addresses the origins of that controversy and determines even if the anxious approach is a privileged website for antisense oligonucleotide motion and never topic to an identical vagaries and pitfalls as non-neuronal platforms.
Modulating Gene Expression by means of Antisense Oligonucleotides to UnderstandNeural Functioning comprises chapters via specialists within the box that target using this method in numerous behavioral platforms, in addition to fast and nonspecific results and the uptake and metabolism of antisense oligonucleotides by way of the apprehensive approach.
Modulating Gene Expression via Antisense Oligonucleotides to UnderstandNeural Functioning good points:
- experts within the box reporting at the use of antisense oligonucleotide know-how in various behavioral structures, together with ache regulate, circadian rhythms, ingestion and keep an eye on of water stability, and reproductive behaviors;
- the novel use of plasmids to specific antisense RNA within the apprehensive method;
- the biodistribution and metabolism of antisense oligonucleotides within the worried process;
- rapid and strange results; and
- non-specific effects.
Read Online or Download Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning PDF
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Extra resources for Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning
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