Modulating Gene Expression by Antisense Oligonucleotides to by Margaret M. McCarthy (auth.), Margaret M. McCarthy (eds.)

By Margaret M. McCarthy (auth.), Margaret M. McCarthy (eds.)

When first brought, antisense oligonucleotides have been hailed because the lengthy awaited magic bullet that might supply an remarkable point of specificity in controlling gene expression. Following this preliminary enthusiasm, antisense oligonucleotides were maligned as nonspecific, poisonous, and basically dead. despite the fact that, program of antisense oligonucleotide know-how within the apprehensive process stands except using this system in peripheral platforms, principally due to its huge, immense good fortune. The resource of this good fortune continues to be an issue of a few controversy.
Modulating Gene Expression by way of Antisense Oligonucleotides to UnderstandNeural Functioning addresses the origins of that controversy and determines even if the anxious approach is a privileged website for antisense oligonucleotide motion and never topic to an identical vagaries and pitfalls as non-neuronal platforms.
Modulating Gene Expression by means of Antisense Oligonucleotides to UnderstandNeural Functioning comprises chapters via specialists within the box that target using this method in numerous behavioral platforms, in addition to fast and nonspecific results and the uptake and metabolism of antisense oligonucleotides by way of the apprehensive approach.
Modulating Gene Expression via Antisense Oligonucleotides to UnderstandNeural Functioning good points:

  • experts within the box reporting at the use of antisense oligonucleotide know-how in various behavioral structures, together with ache regulate, circadian rhythms, ingestion and keep an eye on of water stability, and reproductive behaviors;
  • the novel use of plasmids to specific antisense RNA within the apprehensive method;
  • the biodistribution and metabolism of antisense oligonucleotides within the worried process;
  • rapid and strange results; and
  • non-specific effects.

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Nuclear accumulation of microinjected antisense oligonucleotides. Nucleos Nucleot 1991b;1O:537-539 Li B, Hughes lA, Phillips MI. Uptake and efflux of intact antisense phosphorothioate deoxyoligonucleotide directed against angiotensin receptors in bovine adrenal calls. Neurochem Int 1997;31 :393-403 Liu PK, Salminen A, He YY, liang MH, Xue II, Liu IS, Hsu CY. Suppression of ischemia-induced fos expression and AP-l activity by an antisense oligodeoxynucleotide to c-fos mRNA. Ann Neurol 1994;36:4566-4576 Loke SL, Stein CA, Zhang XH, Mori K, Nakanishi M, Subasinghe C, Cohen IS, Neckers LM.

Antisense oligodeoxynucleotides to NMDA-Rl receptor channel protect cortical neurons from excitotoxicity and reduce focal ischemic infarctions. Nature 1993a;363:260-263 Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M. Modulation of anxiety and neuropeptide Y-YI receptors by antisense oligonucleotides. Science 1993b;259:528-531 Weiss B, Davidkova G, Zhang SOP. Antisense strategies in neurobiology. Neurochem Int 1997;31:321-348 Whitesell L, Geselowitz D, Chavany C, Fahmy B, Walbridge S, Alger JR, Neckers LM.

In the rat. Psychopharmacology 1976;50:89-94 Probst JC and Skutella T. The G-tetrad in antisense targeting. Trends Genetics 1996;12:290-291 Reddy DS. Antisense oligonucleotides - a new class of potential anti-AIDS and anticancer drugs. Drugs of Today 1996;32:113-137 Rothwell NJ. CRF is involved in the pyrogenic and thermogenic effects of interleukin IB in the rat. Am J PhysioI1989;256:EIII-EII5 Sarmiento UM, Perez JR, Becker JM, Narayanan R. In vivo toxicological effects of rei A antisense phosphorothioates in CD-I mice.

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