Modern Biocatalysis: Stereoselective and Environmentally by Wolf-Dieter Fessner, Thorleif Anthonsen

By Wolf-Dieter Fessner, Thorleif Anthonsen

This reference covers the huge and speedily transforming into box of biocatalysis. It combines complementary services from such parts as microbiology, enzymology, molecular biology structural biology and natural chemistry, hence highlighting the interdisciplinary nature of the topic. With its targeted specialise in growth and new advancements in the direction of environmentally helpful reactions with excessive degrees of selectivity for the creation of key compound periods, this ebook will enlighten either chemists and biologists as to the advances and possibilities current in enzyme catalysis.

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2) [9, 10]. Aldehyde 4 is unstable towards β-elimination in water, but can be handled in organic solvent. For instance, the reaction of aldehyde with silyl enolethers under catalysis by SnCl4 at low temperature in dichloromethane proceeds in excellent yields without β-elimination to deliver a stereoisomeric mixture of aldol 6, which can then be separated by high-performance liquid chromatography for individual assays. The retro-aldol reaction can also be assayed with aldol 7, which follows the same mechanism as 6, as well as with aldols 8 and 9, which directly yield a fluorescent aldehyde product upon retro-aldolization, as shown by List et al.

When Candida rugosa lipase (formerly named Candida cylindracea lipase) was immobilized on an epoxy-activated resin it became resistant against acetaldehyde. 7) [78]. 8). Lyophilized CALB and Novozym 435 were also included in the test. The specific activity (U/g dry immobilized CALB) of Novozym 435 was much lower than for CALB immobilized on the different Sepabeads. In a thermal stability screening, Novozym 435 and CALB immobilized on amino Sepabeads with short spacers displayed equal stability, while all the other CALB preparations were less stable [32].

And Fabrias, G. (2007) Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem, 8, 642–648. , Crotti, P. L. (2002) A selective 52 53 54 55 56 57 58 59 60 HIV-protease assay based on a chromogenic amino acid. Helvetica Chimica Acta, 85, 3090–3098. Klein, G. L. (2001) An enzyme assay using pM. Angewandte Chemie – International Edition, 40, 1771–1773. , Renaudet, O. L. (2003) A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases.

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