Organotellurium Compounds, Vol. E12b by K.J. Ingolic

By K.J. Ingolic

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The effects of anthocyanosides on the capillary filtration in diabetic rats were examined by the use of an in vivo method for measurement of the capillary filtration of albumin (CFA) in rats. Anthocyanosides might effectively prevent the increase in CFA and the failure of the lymphatic uptake of interstitial albumin in the diabetic animals [46]. One of the most serious diabetic complications is retinopathy, which could cause blindness. Retinopathy occurs when the body attempts to repair the leaking and damaged capillaries, which are caused by overproduction of abnormal proteins.

Functionality of Anthocyanins as Alternative Medicine 33 Similarly, myricetin also could compete with ascorbic acid for ascorbate oxidase [86]. Antioxidants are potent scavengers of free radicals and serve as inhibitors of neoplastic processes. A large number of synthetic and natural antioxidants have been demonstrated to induce beneficial effects on human health and prevent many diseases. However, the structure–activity relationships, bioavailability and therapeutic efficacy of the antioxidants might differ extensively.

The efficacy of cyanidin-3-O-glucoside (C3G) on the modulation of their cellular responses following the exposure to UVB doses was examined in human keratinocytes (HaCaT). The UVB-exposed cells stimulated the translocation of the transcription factors such as NF-κB and AP-1, overexpression of the proinflammatory cytokine IL-8, cleavage of procaspase-3 (a key step in apoptotic pathway), and DNA fragmentation. However, all these effects elicited by UVB exposure were clearly inhibited by pretreating the HaCaT cells with C3G.

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