Lung Biology in Health & Disease Volume 171 Sleep-Related by Miodrag Radulovacki

By Miodrag Radulovacki

Systematically assessing the relative strengths and weaknesses of varied animal version structures, this reference offers an outline of the identified pathophysiology of sleep-related respiring problems. It focuses completely on animal-based experimental techniques to enhance present diagnostic and healing practices within the administration of sleep-related respiring problems. offering a primary realizing of sleep-related respiring problems, the e-book introduces sleep issues and applies sleek neuroscience to legislation of respiring in the course of sleep. The authors have accrued approximately all identified reports, summarized the date, and supplied effortless to appreciate diagrams, charts, and figures.

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Additional info for Lung Biology in Health & Disease Volume 171 Sleep-Related Breathing Disorders: Experimental Models and Therapeutic Potential

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Validation data were presented only in the light phase in that study, probably because constant illumination is routinely used in sleep deprivation experiments to dampen or eliminate circadian rhythms (31,34). However, such criteria for detection of sleep-wake states in constant illumination may not be readily applicable to studies using the normal light–dark cycle. In addition, restricting analysis of EEG frequencies to below 15 Hz precludes analysis of a significant portion of EEG frequencies that change across sleep–wake states in rats.

In addition, no clear correlation has been demonstrated between airway or adenotonsillar dimensions and SRBD incidence or severity in children (50,51). Moreover, some children with adenotonsillar hypertrophy as the sole recognizable risk factor are not cured by adenotonsillectomy (49). Finally, one study reported a group of children initially ‘‘cured’’ of obstructive SRBD by adenotonsillectomy who experienced a recurrence of the disorder during adolescence (52). It is now feasible to investigate developmental aspects of SRBD pathogenesis and associated morbidity.

And Scaillet, S. Breathing during sleep in infancy. In: Loughlin, G. , Carroll, J. , and Marcus, C. L. eds. Sleep and Breathing in Children—A Developmental Approach. New York: Marcel Dekker, 2000:405–422. 47. Ali, N. , Pitson, D. , and Stradling, J. R. Snoring, sleep disturbance, and behaviour in 4–5 year olds. Arch Dis Child 1993; 68:360–366. 48. , Tishler, P. , and Graham, G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med 1999; 159:1527–1532.

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