By Hasan Khatib
Chapter 1 Epigenetics of Mammalian Gamete and Embryo improvement (pages 3–25): Nelida Rodriguez?Osorio, Sule Dogan and Erdogan Memili
Chapter 2 Epigenetics of Cloned Preimplantation Embryos of household Animals (pages 27–42): X. Cindy Tian and Sadie L. Marjani
Chapter three Roles of Imprinted Genes in Fertility and delivers of the Genome?Wide applied sciences (pages 43–57): Ashley driving force, Wen Huang and Hasan Khatib
Chapter four Sheep as an Experimental version for Human paintings: Novel Insights on Phenotypic changes in ART?Derived Sheep Conceptuses (pages 59–71): Pasqualino Loi, Antonella D'Agostino, Marta Czernik, Federica Zacchini, Paola Toschi, Antonella Fidanza and Grazyna Ptak
Chapter five The DLK1?DIO3 Imprinted Gene Cluster and the Callipyge Phenotype in Sheep (pages 73–88): Christopher A. Bidwell, Ross L. Tellam, Jolena N. Waddell, Tony Vuocolo, Tracy S. Hadfield and Noelle E. Cockett
Chapter 6 Genomic Imprinting and Imprinted Gene Clusters within the Bovine Genome (pages 89–111): Ikhide G. Imumorin, Sunday O. Peters and Marcos De Donato
Chapter 7 Imprinting in Genome research: Modeling Parent?Of?Origin results in QTL reviews (pages 113–129): Suzanne Rowe, Stephen Bishop and D. J. de Koning
Chapter eight Epigenetics and Animal health and wellbeing (pages 131–145): Juan Luo, Ying Yu and Jiuzhou Song
Chapter nine Epigenetics and MicroRNAs in Animal healthiness (pages 147–160): Fei Tian and Jiuzhou Song
Chapter 10 food and Epigenetics in Bovine Cells (pages 161–177): Cong?Jun Li, Robert W. Li and Ted H. Elsasser
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Extra info for Livestock Epigenetics
DNA methylation is shown as arbitrary units on the y-axis. The DNA methylation level of the preimplantation embryo is the sum of the spermatozoon (blue) and oocyte (pink) methylation. Before the ﬁrst mitotic division, the sperm genome undergoes active demethylation, and the oocyte genome undergoes passive demethylation throughout several cell divisions. Paternal and maternal genomes remain separated until after the four-cell stage. After the eight-cell stage, a small wave of de novo methylation is observed.
Thus, after being formed in the embryo and remaining in “meiotic stand by” for months or even years, the oocyte can only complete its journey with fertilization. 1. FERTILIZATION AND EGG ACTIVATION Once delivered into the female reproductive tract, sperm cells have to travel a long distance and swim against a series of obstacles (the low vaginal pH, the cervix, and the presence of macrophages in the uterus) that serve as the selection machinery preventing abnormal spermatozoa from reaching the egg.
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