By Peter Scott
Chapter 1 normal review (pages 1–23): Scott L. Dax
Chapter 2 Electrophile Cleavable Linker devices (pages 25–76): Michio Kurosu
Chapter three Nucleophile Cleavable Linker devices (pages 77–133): Andrea Porcheddu and Giampaolo Giacomelli
Chapter four Cyclative Cleavage as a Solid?Phase procedure (pages 135–149): A. Ganesan
Chapter five Photolabile Linker devices (pages 151–193): Christian Bochet and Sebastien Mercier
Chapter 6 Safety?Catch Linker devices (pages 195–220): Sylvain Lebreton and Marcel Patek
Chapter 7 Enzyme Cleavable Linker devices (pages 221–238): Mallesham Bejugam and Sabine L. Flitsch
Chapter eight An advent to Diversity?Oriented Synthesis (pages 239–262): Richard J. Spandl, Gemma L. Thomas, Monica Diaz?Gavilan, Kieron M. G. O'Connell and David R. Spring
Chapter nine T1 and T2 – flexible Triazene Linker teams (pages 263–302): Kerstin Knepper and Robert E. Ziegert
Chapter 10 Hydrazone Linker devices (pages 303–315): Ryszard Lazny
Chapter eleven Benzotriazole Linker devices (pages 317–329): Daniel okay. Whelligan
Chapter 12 variety Cleavage concepts from Phosphorus Linkers (pages 331–341): Patrick G. metal and Tom M. Woods
Chapter thirteen Sulfur Linker devices (pages 343–389): Dr Peter J. H. Scott
Chapter 14 Selenium? and Tellurium?Based Linker devices (pages 391–417): Tracy Yuen Sze yet and Patrick H. Toy
Chapter 15 Linker devices Cleaved by way of Radical approaches: Cleavage of Carbon?Sulfur, ?Selenium, ?Tellurium, ?Oxygen, ?Nitrogen and ?Carbon Linkers (pages 419–466): Giuditta Guazzelli, Marc Miller and David J. Procter
Chapter sixteen Silicon and Germanium Linker devices (pages 467–504): Alan C. Spivey and Christopher M. Diaper
Chapter 17 Boron and Stannane Linker devices (pages 505–518): Dr Peter J. H. Scott
Chapter 18 Bismuth Linker devices (pages 519–523): Dr Peter J. H. Scott
Chapter 19 Transition steel Carbonyl Linker devices (pages 525–536): Susan E. Gibson and Amol A. Walke
Chapter 20 Linkers freeing Olefins or Cycloolefins via Ring remaining Metathesis (pages 537–549): Jan H. van Maarseveen
Chapter 21 Fluorous Linker devices (pages 551–576): Wei Zhang
Chapter 22 Solid?Phase Radiochemistry (pages 577–587): Brian G. Hockley, Dr Peter J. H. Scott and Michael R. Kilbourn
Chapter 23 Linker choice Tables (pages 589–655): Dr Peter J. H. Scott
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Extra info for Linker Strategies in Solid-Phase Organic Synthesis
By using a volatile cleavage reagent) and should not introduce impurities that are difficult to remove. Although recent advances in analysis and purification methods have dramatically enhanced the usefulness of solid-phase synthesis using the established linkers, continuous development of new linkers that allow the delivery of target molecules in high yield and purity is required. The examples discussed in this chapter are electrophiles, such as H+ , cleavable linkers. These linkers represent the most widely used linkers in current solid-phase organic synthesis.
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Solid-phase Mannich reactions of a resin-immobilized alkyne, in Solid-Phase Organic Syntheses (ed. A. W. , New York 2001, 45–53. Dax, S. , McNally, J. , and Youngman, M. ; Curr. Med. Chem. 1999, 6 , 255. Patai, S. ); The Chemistry of the Carbon–Carbon Triple Bond, Parts 1–2 , John Wiley & Sons Ltd, Chichester 1978. ; Reaction of Alkynes with Organometallic Reagents in Prep. Alkenes (ed. J. M. J. Williams), Oxford University Press, Oxford 1996, 137. ; Cycloadditions and Cyclizations Involving Triple Bonds, in The Chemistry of the Carbon–Carbon Triple Bond, Parts 1–2 (ed.