By James G. Fox, Bennett J. Cohen and Franklin M. Loew (Eds.)
A quantity within the American collage of Laboratory Animal Medicine sequence, this moment version has over forty% new fabric, together with the addition of six new issues and so on which are thoroughly rewritten. The publication comprehensively covers the organic and ailment elements of laboratory animal medication whereas reading different facets corresponding to the biohazards linked to using animal experimentation and components complicating the bioethics of animal study
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Additional resources for Laboratory Animal Medicine
See Section II,C,2 for information on Canadian provincial legislation. 25 The Home Office, Cruelty to Animals Inspectorate, 50 Queen Anne's Gate, London SW1 H9AT. 4. Other European Countries 3. Great Britain The British Cruelty to Animals Act of 1876 is the oldest of the national laws regulating the use of animals in scientific activities. Although this Act is currently under possible revi sion, amendment, or replacement, its thrust will almost cer tainly remain the same as it has been since 1876.
Perpetuation of breeding system Reference Continue brother-sister mating Poiley (1960) Kimura and Chow (1963) Green (1981) Cannot be perpetuated Continue brother-sister mating Green (1981) Bailey (1971) Perpetuate the mutation by (1) brother-sister mating with in strain or origin, (2) backcross system or crossintercross system with strain of origin as parent strain, (3) brother-sister mating with heterozygosity forced by backcrosses or intercrosses or (4) brother-sister mating with homozygosity forced by incrosses Perpetuate the transferred mutation by (2), (3), or (4) as above Flaherty (1981) Continue brother-sister mating with heterozygosity forced by one of the four methods, as at left, or with homo zygosity forced by intercrossing Green (1981) Continue random mating Flaherty (1981) 36 ROBERT O.
Recombinant inbred strains may take as long as 7 years to produce. However, they are essential for detecting new genetic linkages and inherited traits. There are currently more than 500 separate outbred stocks and inbred strains, some with various sublines. Mutant stocks have also been established and are used as models of human diseases. Therefore, strain or stock designations must be as complete to avoid semantic and genetic confusion. As an ex ample of subline variation, CBA/J carries the gene for retinal degeneration, while CBA/Ca does not.