Immune Mechanisms of Pain and Analgesia by Halina Machelska, Christoph Stein

By Halina Machelska, Christoph Stein

Immune Mechanisms of ache and Analgesia is the 1st quantity to debate a brand new suggestion of immune-neural interplays resulting in soreness or analgesia. It argues the classical view that discomfort and its keep an eye on are limited to the frightened method, providing a entire review of the rising sector of immune mechanisms in discomfort and its keep an eye on. It demanding situations the conventional view that ache sensation or suppression is attributed solely to the fearful procedure and provides a severe research of this new suggestion. The ebook is written by way of an the world over well-known workforce of researchers and discusses complicated and debatable concerns akin to cytokines and their pain-exacerbating but in addition analgesic results, the construction of opioids through immune cells, peripheral analgesic and anti inflammatory activities of opioids, immunomodulatory results of opiates, and immunosuppressive results of ache.

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1 and 2). l. injection of IL-1β produced an acute thermal hyperalgesia and an elevation in cutaneous NGF levels, which could be prevented by pretreatment with human recombinant IL-1 receptor antagonist. 29 NGF, in our version of the rat paw pressure test, produces a dose-dependent hyperalgesia, which reaches a plateau within 1 hour and could be weakly inhibited by pretreatment with propanolol, indomethacin or MK866. Hyperalgesia could be inhibited (by up to 50 %) by pretreatment with three agents, indicating that NGF has either a direct hyperalgesic effect by itself or is releasing another unidentified mediator (unpublished results).

J Neurochem 2000; 74:457-471. 125. Henry JL, Yashpal K, Pitcher GM et al. Evidence for tonic activation of NK-1 receptors during the second phase of the formalin test in the rat. J Neurosci 1999; 19:6588-6598. 126. Palma C, Minghetti L, Astolfi M et al. Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production. Glia 1997; 21:183-193. 127. Cadman ED, Witte DG, Lee CM.

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