Glaucoma by Nicholas E. H. Nick Wood, Li Guo, M. Francesca Cordeiro

By Nicholas E. H. Nick Wood, Li Guo, M. Francesca Cordeiro (auth.), Franz Grehn MD, Robert Stamper MD (eds.)

The necessities in Ophthalmology sequence represents readership reputation of the 1st sequence, each one an specified updating book at the growth in all of 8 volumes. this can be a good fortune that was once made subspecialties of ophthalmology. attainable predominantly by means of the varied opinion-lead- In a quarterly rhythm, 8 matters are released cov- ing authors and the phenomenal part editors, in addition ering clinically proper achievements within the complete box as with the positive help of the writer. There of ophthalmology. This well timed move of developments are many strong purposes to proceed and nonetheless enhance for the absolute best care of our eye sufferers has confirmed the dissemination of this didactic and clinically r- to be powerful. The preliminary operating speculation of provid- evant info. ing new wisdom instantly following e-book within the peer-reviewed magazine and never anticipating the G.K. Krieglstein textbook seems to be hugely doable. R.N. Weinreb we're now coming into the 3rd cycle of the necessities sequence Editors in Ophthalmology sequence, having been inspired by way of September 2008 Preface This 3rd quantity within the sequence, necessities of Oph- worthwhile. Strouthidis and Garway-Heath let us know how.

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The relationship of aqueous flow dynamics to 24H IOP remains unclear. Aqueous production is known to decrease by 50–60% at night [8]. However, IOP rises during the nocturnal period, partly due to positional changes [5, 7]. An increase in EVP may contribute to this rise [9]. However, when data is collected in a supine position over 24H, fluctuations in IOP are still present [5]. This underlying fluctuation in IOP suggests circadian control of IOP. This control is independent of ambient lighting and changes in corneal biomechanical properties [10, 11].

Still, the persistence of these rhythms in patients with Horner syndrome may indicate an additional source of biochemical regulation of aqueous flow. ■ ■ IOP is highest in the habitual positions during the nocturnal period Prostaglandin analogs and carbonic anhydrase inhibitors more effectively lower IOP during the nocturnal period than beta-adrenergic antagonists The importance of 24H IOP, particularly the nocturnal (sleep) values, has not yet been elucidated. Nevertheless, IOP remains the only clinically modifiable risk factor for glaucoma.

1) [5, 7]. When IOPs were measured while subjects were in a supine position throughout the 24H study, the nocturnal rise in IOP, though present, fitted within a biphasic IOP curve with two peaks within 24H. The relationship of aqueous flow dynamics to 24H IOP remains unclear. Aqueous production is known to decrease by 50–60% at night [8]. However, IOP rises during the nocturnal period, partly due to positional changes [5, 7]. An increase in EVP may contribute to this rise [9]. However, when data is collected in a supine position over 24H, fluctuations in IOP are still present [5].

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