General Principles by A. G. Lee

By A. G. Lee

Hardbound. development in realizing the character of the organic membrane has been very fast over a large entrance, yet nonetheless wallet of lack of information stay. program of the thoughts of molecular biology has supplied the sequences of a truly huge variety of membrane proteins, and has ended in the invention of superfamilies of membrane proteins of similar constitution. In flip, the id of those superfamilies has ended in new methods of brooding about membrane methods. lots of those procedures can now be mentioned in molecular phrases, and unforeseen relationships among it sounds as if unrelated phenomena are bringing a brand new team spirit to the examine of organic membranes. the volume of knowledge on hand approximately membrane proteins is now too huge for anyone individual to be acquainted with whatever yet a really small a part of the first literature. a chain of volumes focusing on molecular features of organic membranes for this reason turns out well timed. The wish is th

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PLES OF MEMB RAN E PROTEIN STRUCTURE M. S. P. Sansom and lan D. Kerr I. II. IlI. IV. VI. Introduction . . . . . . . . . . . . . . . . . Classification of M e m b r a n e Proteins . . . . . . . . . . . . A. Integral and Peripheral M e m b r a n e Proteins . . . . . . . . B. Single T M Helices . . . . . . . . . . . . . . C. A l l - ~ Topologies . . . . . . . . . . . . . . D. All-~ Topologies . . . . . . . . . . . . . . .

Two views of the seven-helix bundle are shown. A is down a perpendicular to the plane of the bilayer, showing the s-carbon traces of the seven TM helices. The same helices are shown in "ribbon" format in B, in a view approximately perpendicular to that in A. The individual helices and the N- and C-termini of the polypeptide chain are labeled. Interhelix loops are omitted from both diagrams. , 1977). 36 Table 3. ga L1 L2 L3 L4 L5 M1 M2 M3 M4 M5 H1 mean + SD P 13 P12 P20 Loop A-B B-C C-D D-E E-F F-G Length 5 17 7 9 9 11 23 + 2 mean + SD 10 + 4 21 29 26 30 27 27 30 26 29 27 26 P4, P 10 P2 L l-L2 L2-L3 L3-L4 L4--L5 28 2 29 25 P22 P2 M l-M2 M2-M3 M3-M4 M4-M5 31 2 29 33 mean + SD 22 + 12 27 + 2 Note: aNumber indicates position of the proline within the TM helix.

Classification of Integral Membrane Proteins Class Description all-o~ bundle of TM u-helices all-13 ~13 antiparallel l-barrel o~-helicesand 13-strandsin the sameTM domain Members bacteriorhodopsin halorhodopsin rhodopsin photosyntheticreaction centers light harvestingcomplex photosystemI porins nicotinicacetylcholinereceptor K+ channels? P. SANSOM and IAN D. KERR bundles in which the hydrophilic surfaces of the helices line a central pore or binding site. D. , Capaldi, 1982). However, since the determination of high-resolution structures of several porins, it has become evident that a [5-sheet may also yield a stable TM fold (Figure 1C; Table 2).

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