By Arne Brun, Elisabet Englund, Lars Gustafson, Ulla Passant
This booklet covers the shows held on the 'International convention on Frontotemporal Dementias' (FTD) in Lund, Sweden, in 2003. the purpose of the papers isn't just to offer contemporary growth of scientific and uncomplicated study, but in addition to provide an summary of the genetics best as much as new entities reminiscent of FDT-17 and FDT-3. medical and pathological variations of the 3 key varieties of FDT, Pick's affliction, frontal lobe degeneration of non-Alzheimer kind and motor neuron illness with dementia are defined in addition to linked stipulations equivalent to semantic dementia and innovative non fluent aphasia. The scientific research focuses upon cognition, character, emotional and social habit in FTD correlated with neuroimaging, pathology, and genetic and neurochemical findings. additional, the factors of early analysis, pharmacological remedy and techniques for administration and care are mentioned and analyzed.
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Additional info for Frontotemporal Dementias: 4th International Conference, Lund, Sweden, April 24-26 2003
We describe the early clinical, neuropsychological and brain imaging findings as well as the results from followup investigations in 5 patients belonging to the same family. Episodic memory failure was the initial symptom in all patients, indicating hippocampal involvement. Over time, however, increasing personality and behavioural disturbances suggest additional frontal dysfunction. Subjects The pedigree presents 7 dementia cases. However, we have data on only 5 cases (fig. 1). The age of onset varies from 54 to 62 years (table 1).
14 Boccardi M, Pennanen C, Laakso MP, Testa C, Geroldi C, Soininen H, Frisoni GB: Amygdaloid atrophy in frontotemporal dementia and Alzheimer’s disease. Neurosci Lett 2002;335: 139–143. 15 Hornak J, Bramham J, Rolls ET, Morris RG, O’Doherty J, Bullock PR, Polkey CE: Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain 2003;126:1691–1712. 16 Delis DC, Kramer JH, Kaplan E, Ober BA: California Verbal Learning Test, ed 2. San Antonio, The Psychological Corporation, 2000.
There was no evidence that any of these deficits were due to difficulties with visual 280 Dement Geriatr Cogn Disord 2004,17:277–281 perception, as both groups included only patients who performed well in facial identity discrimination. Furthermore, our findings are consistent with those of previous studies in which fvFTD patients have shown impaired recognition of both facial and vocal expressions of negative emotions and happiness . These findings naturally lead to the question of what neuropathological changes underlie emotion recognition deficits in these two groups.