Eosinophilic Esophagitis by Chris A. Liacouras MD, Chris A. Liacouras MD (auth.), Chris

By Chris A. Liacouras MD, Chris A. Liacouras MD (auth.), Chris A. Liacouras, Jonathan E. Markowitz (eds.)

This quantity offers a heritage of Eosinophilic Esophagitis (EoE), a uncomplicated figuring out of the body structure of the eosinophil, and a present figuring out of the pathophysiology and genetics of EoE. The emphasis is on scientific purposes together with featuring indicators, analysis and treatments for sufferers with EoE. Written via either pediatric and grownup specialists within the fields of gastroenterology, hypersensitive reaction and pathology, this quantity comprises the freshest info.

Providing functional details invaluable within the remedy of sufferers, this publication may be of serious worth to gastroenterologists, allergists, pathologists, clinical citizens, fellows, internists, and basic practitioners who deal with sufferers with eosinophilic esophagitis.

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Example text

SSAAD;15] et al. [14] Spergel [16] et al. 4). While estimates vary, demographic studies of atopic diseases in children report a prevalence of 6% for asthma, 15% for allergic rhinitis, 10% for eczema, and 3% for food allergy [32–34]. 3-, 4-, and 2-fold for asthma, rhinitis, and eczema, respectively [16]. While the EXACT MECHANISM FOR THE STRONG ASSOCIATION WITH ATOPIC DISEASE IS UNKNOWN IT IS LIKELYTHAT%O%ANDOTHERATOPICDISEASESSHARECOMMON4HINmAMMATORYMEDIAtors. Outside of animal models [35= NO DATA EXIST TO SUGGEST THE MECHANISM BY which asthma (or any other atopic process) promotes EoE in children.

Conversely, esophaGEAL MUCOSAL EOSINOPHILIA OCCURS AS A RESULT OF ACID REmUX DISEASE AND CAN BE reversed with acid-suppressant medications [52]. Disruption of the Esophageal Epithelial Barrier Contributes to EoE $ILATEDINTERCELLULARSPACESHAVEBEENIDENTIlEDINADULTSWITHNON
EROSIVEREmUX DISEASE ALLOWINGTHEPOSSIBILITYTHATREmUX
RELATEDINCREASEDINTERCELLULARPERMEABILITY MAY EXPOSE THE ESOPHAGEAL MUCOSA TO UNPROCESSED DIETARY ANTIGENS ;53]. Furthermore, microarray transcriptional studies from esophageal mucosal biopsies have identified overrepresented filaggrin loss-of-function mutations in a population of EoE patients when compared to healthy controls [54].

Dig Dis Sci. 1993;38(1):109–16. 5. Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic ESOPHAGITISATTRIBUTEDTOGASTROESOPHAGEALREmUXIMPROVEMENTWITHANAMINOACID
BASEDFORmula. Gastroenterology. 1995;109(5):1503–12. 2 Epidemiology, Incidence, and Prevalence of EoE in Children 21 6. Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia PREDICTS RESPONSE TO CONVENTIONAL GASTROESOPHAGEAL REmUX THERAPY 0EDIATR $EV 0ATHOL 1999;2(1):15–8.

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