By Joseph R. Bertino
Because the ebook of the 1st variation of the Encyclopedia of melanoma, an grand volume of recent details has been disseminated within the box of melanoma examine. This moment variation strives to trap the advances taking place within the etiology, prevention, and therapy of melanoma, from easy technological know-how to scientific program. by means of offering concise expositions on a vast diversity of themes, the Encyclopedia is a superb source for these looking info past their particular parts of workmanship. Written by means of a amazing panel of authors, entries hide numerous features of melanoma equivalent to oncology, immunology, epidemiology, gene remedy, oncogenes/tumor suppressor genes, and pharmacology. This amazing reference is vital for someone considering the examine or therapy of melanoma. a web model of the Encyclopedia of melanoma is out there on ScienceDirect. stopover at http://info.sciencedirect.com/reference_works/ for touch and subscription info. entry suggestions can be found whether you are not an current ScienceDirect shopper! Key positive factors* Covers all points of melanoma, segueing from easy technological know-how to medical issues* contains an extra quantity to include all of the new advances within the etiology, prevention, and remedy of melanoma made because the first version* handy association employs common access layout for speedy and straightforward reference* vast cross-referencing presents reader with broader diversity of information* Contributions solicited from one of the best names in quite a few fields
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Additional info for Encyclopedia of Cancer, Four-Volume Set, Vosl. 1-4, 2nd Edition
Jung, S. , and Pastan, I. (1994). Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered 77 into conserved framework regions. Biochemistry 33(18), 5451–5459. Strom, T. , Anderson, P. , Rubin, K. , Williams, D. , and Murphy, J. R. (1990). Immunotoxins and cytokine toxin fusion proteins. Semin. Immunol. 2(6), 467–479. Studier, F. , and Moffatt, B. A. (1986). Use of bacteriophage T7 polymerase to direct selective expression of cloned gene. J. Mol. Biol. 189, 113–130.
In all cases, the antitumor immune response was characterized by the induction of antibodies against the tumor antigen. In a few cases, it was possible to demonstrate a delayedtype hypersensitivity (DTH) reaction against tumor cells, suggesting recruitment of TH cells, although A N T I - I D I O T Y P I C A N T I B O D Y VA C C I N E S more detailed T-cell studies have not been reported. Only a very few studies have assessed whether the antitumor immune response induced by the antiidiotypic antibody provided any protective effect; in the few studies reporting tumor protection, the effect was incomplete.
And Chapman, P. B. (1999). Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus BCG. Clin. Cancer Res. 5, 1319–1324. Greenspan, N. , and Bona, C. A. (1993). Idiotypes: Structure and immunogenicity. FASEB J. 7, 437–444. Jerne, N. K. (1974). Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur) 125, 373–389. Kennedy, R. , Melnick, J. , and Dreesman, G. R. (1986) Anti-idiotypies and immunity. Sci. Am. 255, 48–56.