By Robert J Amato
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3. Standardized gene expression levels of the 145 genes composing the HIF and VHL signaling pathway in ccRCC (upper yellow bar) and normal samples (upper blue bar). Each row represents a single gene and each column an experimental sample. Genes are ordered according to GSEA enrichment score. The map has been obtained using the hierarchical clustering of dChip (Li & Wong, 2001). We finally investigated whether exists a grade-dependent specific transcriptional signature and compared the two groups of ccRCC cases previously classified as high (G3 and G4) and low grade (G1 and G2) classes.
Natl. 100, pp. 1260–12662. ; Lee, S. (2006). p53 Stabilization and Transactivation by a von Hippel-Lindau Protein. 22, pp. 395-405. ; Chen, F. (1997). Germline and Somatic Mutations in the Tyrosine Kinase Domain of the MET Protooncogene in Papillary Renal Carcinomas. 16, pp. 68–73. ; Nakaigawa, N. (1999). Novel Mutations of the MET Proto-oncogene in Papillary Renal Carcinomas. 18, pp. 2343–2350. ; Warren, M. (2005). Germline BHD Mutation Spectrum and Phenotype Analysis of a Large Cohort of Families with Birt–Hogg–Dube Syndrome.
3 (from 35 to 60 Mb) (Figure 6, panel A). , the HGU133A arrays) did not allow a finer resolution of the chromosomal segments as compared to Cifola dataset. B. 22 21 20 19 18 17 16 15 14 13 12 11 10 9 8 7 6 5 4 3 2 1 Chromosome Chromosome A. 0 20 40 60 80 100 120 140 160 180 200 220 240 Position (Mb) 22 21 20 19 18 17 16 15 14 13 12 11 10 9 8 7 6 5 4 3 2 1 0 20 40 60 80 100 120 140 160 180 200 220 240 Position (Mb) Fig. 6. SODEGIR amplified (red) and deleted (green) chromosomal regions identified by preda in the integrative analysis of gene expression and copy number data for Cifola (panel A) and Beroukhim dataset (panel B).