Ciba Foundation Symposium 146 - Photosensitizing Compounds:

Sure natural compounds can develop into poisonous to organic tissue while activated by means of mild. Many scientific purposes of this impact were studied during the last two decades, and This symposium brings jointly chemists, biologists, and clinicians to debate the elemental chemistry of the sensitizing compounds, their organic results, and medical functions in remedies of assorted cancers and dermis issues.

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Why can't we take advantage of the greater absorption? van Lier: We hope that autoradiography with the 14C-labelIedsulphonated phthalocyanines will answer that. Efficiency of tumour kill must be related not only to the tissue distribution of the photosensitizer, but even more so to the distribution within the tumour. Apparently many of these substituted Pcs localize in areas where they cannot do as much damage as anticipated. Dougherty: Is this related to the degree of sulphonation of the dyes?

Jori: What determines selectivity? Some closely related structures show very different selectivities according to this analysis. Berenbaurn: We think this is mainly a question of localization. 56 respectively) and their other photophysical properties are similar (Bonnett et al 1987, Berenbaum & Bonnett 1989). The illumination wavelengths used for the THPPs and THPCs are in the narrow range 648-656 nm. Their different selectivities cannot be accounted for by photophysical differences. Differences in localization are likely to be the governing factor, and this is a question of physical chemistry, not photochemistry.

2 20 200' 1 10 100- 0 0 0 10 50 100 0 Photofrin II (pglkg) FIG. 1. (Berenbaurn) Dose-response curves for tumour necrosis, skin oedema and muscle oederna in mice sensitized with Photofrin 11. Tumour (subcutaneous PC6) and muscle (posterior aspect of leg) were illuminated one day and skin was illuminated three days after sensitization, The light dose was 10 J/cmZ at 625 nm for all tissues. Depth of turnour necrosis was measured as described in Berenbaurn et a1 (1982). Skin oedema was measured 4 h after illumination by weighing a 1 cm disc of illuminated skin (Berenbaum et al 1986), and muscle oedema (also at 4 h) by weighing the dissected posterior compartment leg muscles.

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