Ciba Foundation Symposium 129 - Autoimmunity and Autoimmune

This paintings specializes in the autoimmune methods that experience now been confirmed to underlie a couple of severe illnesses, together with diabetes mellitus, rheumatoid arthritis and a number of sclerosis. Papers discover the speedily increasing advancements in study on immune reaction and rules, and their strength within the improvement of remedies for autoimmune illnesses. the big variety of topics lined right here contain: the character of intracellular and telephone surface-derived ``self'' antigens; competing theories of the iteration of immune tolerance and their implications of present theories for study and therapy; attainable hyperlinks among autoimmunity and genetic supplement deficiency; the contributions of interferons and sophistication II HLA antigen expression to autoimmunity; and the possibility of monoclonal antibodies and different biotechnological advances in treating human autoimmune stipulations.

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Lachmann: The significant immunological difference that you describe between the susceptible and resistant mice is the specificity of the antibody, whereby the susceptible mice are making antibodies to cardiac-specific myosin. Is this the pathogenic antibody, or does the antibody in resistant mice not get to the heart? More specifically, do the antibodies made in resistant mice by immunization with myosin also stop the beating of the myocytes in culture? Rose: The antibody evoked by immunizing resistant mice is a result of adjuvant-mediated polyclonal stimulation.

Current knowledge in this area allows us to formulate questions and theories about the aetiology and pathogenesis of autoimmune diseases. It appears at present that information has accumulated more rapidly than our ability to comprehend its full significance. 3 FIG. 4. A pattern of 11 specific polypeptides is precipitated from "S-labelled HeLa cells by sera containing anti-PM-Scl (lanes 2-7). Lane 1 is normal serum; lane 8 shows molecular weight markers. One of the obvious issues concerns the distinctiveness of the immune response in each of the autoimmune diseases.

Lntracellularautoantigens 31 regions of chromosomes, and specifically at the kinetochore plate proteins of these regions (Moroi et a1 1980). Antibody to kinetochore occurs in 75 to 90% of patients with a subset of scleroderma called CREST (acronym for calcinosis, Raynaud’s phenomenon, oesophageal dysmotility, sclerodactyly and telangiectasia). The anti-centromere/kinetochore antibody has established the separate existence of CREST as a distinct entity. The anti-topoisomerase I and anti-kinetochore antibodies occur independently and it appears to be very unusual to find a patient with both antibodies.

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