Chronobiology and Obesity by Fred W. Turek Ph.D. (auth.), Marta Garaulet, Jose M. Ordovás

By Fred W. Turek Ph.D. (auth.), Marta Garaulet, Jose M. Ordovás (eds.)

Circadian rhythms are such an innate a part of our lives that we infrequently pause to take a position why they even exist. a few reports have instructed that the disruption of the circadian method could be causal for weight problems and manifestations of Metabolic Syndrome (MetS). Shift-work, sleep-deprivation and bright-light-exposure at evening are relating to elevated adiposity (obesity) and occurrence of MetS. it's been supplied proof of clock genes expression in human adipose tissue and confirmed its organization with diversified elements of the MetS. additionally, present reviews are illustrating the actual position of alternative clock genes variations and their envisioned haplotypes in MetS.

The objective of “Chronobiology and weight problems” is to explain the mechanisms implicated within the interplay among chonodisruption and metabolic-related health problems, resembling weight problems and MetS, with assorted approaches.

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Among the last of these, are included circalunar (»28 days), circannual (365 days) and circaseptan (7 years) rhythms. One of the principal properties of biological rhythms is that they persist in the laboratory under constant environmental conditions (free running), that is, they have an endogenous character [36]. A. Madrid Pérez cycles. This property, known as synchronisation capacity, automatically corrects the delays or advances produced daily in clock functioning [35]. For an environmental factor to act as synchroniser or zeitgeber, its period must be very stable, so that it is unsurprising that the main synchroniser is the light–dark cycle.

The most straightforward is RT-PCR, which enables us to qualitatively evaluate which genes are being expressed at the time of sampling. To know which genes are being expressed and its quantification, a quantitative PCR (Q-PCR) or a real time PCR is normally used. 2 An Introduction to Chronobiology 23 Since it is not possible to evaluate clock gene expression in the SCN in vivo, samples obtained from peripheral tissues are used. In this case, there are two main options: evaluate gene expression in leukocytes or in the oral mucosa.

Gómez-Abellán and M. Garaulet Within adipose tissue, TNFa is expressed by adipocytes and stromovascular cells [7] and nowadays we know that this cytokine is able to repress genes involved in uptake and storage of nonesterified fatty acids and glucose; it also suppresses genes for transcription factors involved in adipogenesis and lipogenesis; it changes the expression of several adipocyte-secreted factors including adiponectin and is capable of impairing insulin signaling [8, 9]. In this context, TNFa production is increased in obesity and it has been implicated in the development of insulin resistance in the adipocyte of the obese by altering insulin signaling through an autocrine or paracrine action.

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