By Thomas Arendt (auth.), Agata Copani M.D., Ph.D., Ferdinando Nicoletti M.D. (eds.)
Cell-Cycle Mechanisms and Neuronal mobilephone loss of life examines the function of phone cycle activation within the molecular mechanisms resulting in neuronal degeneration. major Authors speak about this subject on the subject of the foremost neurological problems, together with Alzheimer’s ailment, stroke and epilepsy. This e-book serves to realize new insights into the molecular determinants of neuronal loss of life and to set up new pursuits for healing intervention.
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Additional resources for Cell-Cycle Mechanisms and Neuronal Cell Death
This result indicates that cells contain regulatory proteins that serve dual roles, in mitogenic control and aging, and that a shift in the exquisite balance between these two states would accelerate one process over the other. In the case of presenilins, there is now good evidence that indicates that the level of presenilin expression can dictate whether a cell proliferates or dies: too little expression leads to proliferation in certain cells whereas too high expression causes cell cycle arrest or apoptosis.
Cyclin-dependent kinases as potential targets to improve stroke outcome. Pharmacol Ther 2002; 93:135. 49. Jordan-Sciutto KL, Dorsey R, Chalovich EM et al. Expression patterns of retinoblastoma protein in Parkinson disease. J Neuropathol Exp Neurol 2003; 62:68-74. 50. Ranganathan S, Bowser R. Alterations in G ( l ) to S phase cell-cycle regulators during Amyotrophic lateral sclerosis. Am J Pathol 2003; 162:823-835. 5 1 . Husseman J W , Nochlin D , Vincent I. Mitotic activation: A convergent mechanism for a cohort of neurodegenerative diseases.
Goedert M , Spillantini M G . Tau gene mutations and neurodegeneration. Biochem Soc Symp 2 0 0 1 ; 67:59-71 5. Lee V M , Goedert M , Trojanowski J Q . Neurodegenerative tauopathies. Annu Rev Neurosci 2 0 0 1 ; 24:1121-1159 6. Vassar R, Bennett BD, Babu-Khan S et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286:735-741. 7. Selkoe DJ, Wolfe MS. In search of gamma-secretase: Presenilin at the cutting edge. Proc Natl Acad Sci USA 2000; 97:5690-5692.