Cardiology of The Horse by Celia Marr BVMS MVM PhD MRCVS, Mark Bowen BVetMed PhD

By Celia Marr BVMS MVM PhD MRCVS, Mark Bowen BVetMed PhD CertEM(IntMed) MRCVS

A multi-contributed, state of the art reference on equine cardiology. Divided into three sections, the textual content covers body structure and pharmacology, diagnostic recommendations, and scientific difficulties. studies fresh advancements in learn and perform. comprises a variety of colour and black-and-white illustrations.

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Vet Res 27:363–372. Gehring R, Baynes RE, Craigmill AL, Riviere JE (2004). Feasibility of using half-life multipliers to estimate extended withdrawal intervals following the extralabel use of drugs in food-producing animals. J Food Prot 67:555–560. Giantin M, Carletti M, Capolongo F, Pegolo S, Lopparelli RM, Gusson F, Nebbia C, Cantiello M, Martin P, Pineau T, Dacasto M (2008). Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver. Drug Metab Dispos 36(5):885–893.

Different doses, or different routes of administration), the codified 40 Evaluation of Drug Residue Depletion in the Edible Products t­olerance is the lowest of all the tolerances that may be calculated based on the available data for supporting the drug product approvals in that species. The target tissue, marker residue, and tolerance assignments usually rely on the residue chemistry information obtained from the total residue depletion and drug metabolism studies. 1 Total Residue Depletion Study Generally, the first residue chemistry study a sponsor conducts is the study that monitors drug metabolism and depletion of total residues in the tissues and excreta of the target animals.

Published 2014 by John Wiley & Sons, Inc. 35 36 Evaluation of Drug Residue Depletion in the Edible Products The drug residues considered in human food safety evaluation include not only the active pharmaceutical ingredient(s) and excipient(s) of a drug product but also their metabolites and any substance formed in or on the edible food products as a result of drug treatment. For antimicrobial products, drug residues may include antimicrobial-resistant bacteria. Animal drug products may be xenobiotics, containing compounds foreign to the target (food-producing) animals (including modified compounds of endogenous origin), or endogenous compounds naturally present in the target animals and humans.

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