Cardiac Arrhythmias 1995: Proceedings of the 4th by G. Turitto (auth.), Antonio Raviele MD (eds.)

By G. Turitto (auth.), Antonio Raviele MD (eds.)

The topic of cardiac arrhythmias is of sensible relevance. a number of arrhythmias are present in diverse scientific occasions, resembling untimely complexes in fit contributors, supraventricular tachyarrhythmias in sufferers with Wolff-Parkinson-White snydrome, atrioventricular block, and ventricular traumatic inflammation in cardiopathic stipulations, specially in sufferers with ischemic disorder. themes of significant curiosity are mentioned during this quantity: malignant ventricular arrhythmias, unexpected loss of life, computerized implantable cardioverter defibrillators, syncope, present symptoms for pacing remedy, radiofrequency catheter ablation, flutter, and atrial fibrillation.

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Extra resources for Cardiac Arrhythmias 1995: Proceedings of the 4th International Workshop on Cardiac Arrhythmias (Venice, 6–8 October 1995)

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Di Carlo LA, Morady F, Sauve MJ et al (1985) Cardiac arrest and sudden death in patients treated with amiodarone for sustained ventricular tachycardia or ventricular fibrillation: risk stratification based on clinical variables. Am J Cardiol 55: 372374 48. Horowitz LN, Greenspan AM, Spielman SR et al (1985) Usefulness of electrophysiologic testing in evaluation of amiodarone therapy for sustained ventricular tachyarrhythmias associated with coronary heart disease. Am J Cardiol55: 367-371 49. Manolis AS, Uricchio F, Estes M (1989) Prognostic value of early electrophysiologic studies for ventricular tachycardia recurrence in patients with coronary artery disease treated with amiodarone.

Clinical results of empirical amiodarone treatment: cardiac (CM) and total mortality (TM) rates ('Yo) Reference Patients (n) 1-year CM TM 3-year CM TM 5-year CM TM (60) (61) (62) (54) 427 469 128 52 0 0 26 28 31 0 37 37 31 11 18 11 24 13 21 0 43 33 34 0 62 46 42 0 sustained VT or VF (62). The average age was 62 years, and the mean ejection fraction 36%. A total of 81 % of patients had coronary artery disease. After 1, 3 and 5 years, the sudden death rate was 9%, 16% and 20%, the total cardiac death rate was 18%, 28% and 37%, and the nonfatal VT recurrence rate was 5%, 15%, and 25% respectively.

All such agents blocked sodium-channel activity to varying degrees and had somewhat different offset and onset kinetics of sodium-channel block. In general these are powerful suppressants of PVCs but given the context of serious cardiac disease, they all may increase mortality, presumably by inducing serious life-threatening ventricular arrhythmias (3, 6, 7). They may increase sudden. death and may produce incessant VT/VF which may be difficult to cardiovert or defibrillate. As a class these agents have not been shown to reduce mortality in any subset of patients with cardiac disease.

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