By Edited by Hiroshi Wada
This publication is key interpreting for these drawn to figuring out present tendencies of analysis within the sector of biomechanics at micro- and nanoscale degrees. It information the learn conducted thus far during this box via fourteen favorite researchers as a part of a four-year govt supported undertaking which began in 2003. It contains 4 chapters entitled phone Mechanics, cellphone reaction to Mechanical Stimulation, Tissue Engineering and Computational Biomechanics.
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Extra info for Biomechanics at micro-and nanoscale levels
Also, even with increased cell separation distance from 50 to 75 µm, the signal transmission speed was not significantly reduced, supporting the idea that the signal transmission is not due to diffusion of secreted factors. 5 µm/sec . The peak magnitudes of calcium responses in neighboring cells were significantly lower than that of the indented cell. However, the peak magnitudes 28 X. E. Guo et al. were not decreased with transmission between other neighboring cells, such as cells 1 step away and 2 steps away.
However, there was no significant difference between the response magnitudes of cells 1 step or 2 steps away for either separation distance. There was a significantly smaller percentage of responsive cells 2 cell steps away in networks with a 75 µm separation distance compared to those with a 50 µm separation distance (Fig. 10). However, there was no difference in the percentage of responsive cells 1 cell step away, or directly adjacent to the indented bone cell, regardless of the cell separation distance.
In the experiment shown, a single cell was tracked at five levels of increasing substrate stretch, with strain transfer from substrate to cytoplasm linear across a range of substrate strains in the direction of applied stretch. In contrast, transfer to the nucleus initially remained close to zero but increased distinctly above a threshold substrate strain. Thus, examining single cell responses may provide more detailed understanding of strain transfer behaviors and reduce confounding effects of biological intercellular variability.