By Chong-Ren Yang, Osamu Tanaka
Hardbound. within the plant nation various chemical ingredients take place in a glycoside shape (conjugation with sugar). Glycosides are very important, secondary metabolites. The structural variety is because of the the colossal quantity of types and stereochemical configurations of the sugar part. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, different uncomplicated phenolics, and isothiocyanate. even though, organic actions of glycosides are, in lots of instances, at risk of the character of sugar moieties, even if their aglycone is the same.Since the 80s, plant glycosides were attracting an expanding quantity of curiosity from botanists and phytochemists world-wide for the subsequent purposes: - they're tough to isolate and purify- they've got a crucial organic functionality in flora and memorable organic actions- they're a extremely important source of common medication, well-being meals, cosmetics and f
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Additional resources for Advances in Plant Glycosides, Chemistry and Biology, Proceedings of the International Symposium in Plant Glycosides
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4, t. : . : . :4. 5 Wistar c? o. ,. o. ** . 01 ) I Inhibitory Effects of 30, 32, 43, 44, and 45 on Glucose Uptake in Rat Small Intestine] Fragments ( I n V i t r o ) ! ~ ** ~~9"/;///Z///////]--~ ** Oleanolic acid 3-O-glucuronide (30) ~ / / / / / / / / / / / / / / / / / / / / / ~ ** / ',,/. /)'227/2Z4~ Escin Ia (43) ~///////////////////~ ///, ** ~ ' / / / ' / ' / ' / / , , . 99 Escin IIa (44) ~ / / / / / / / / / / / / / / / / / / / A ~ ** /. 77•777777•,, Phlorizin ~ ' : ~ , : ~ ; ~ ** ** 0 20 40 gO 8'0 100 Uptake (%) fragments of everted rat intestine incubated with 14C-U-glucose(2 mM) at 30~ 6 min.
However, those glycosides showed no significant effects on serum glucose levels in normal rats, intraperitoneal glucose-loaded rats, and alloxan-induced diabetic mice. These results indicated that the glycosides had neither insulin-like activity nor insulin -releasing activity like tolbutamide, and therefore the glycosides (30, 32, 43, 44, 45) were seemed to affect glucose absorption the gastro-intestinal tract. As shown in Chart 7, the glycosides (30, 32, 43, 44, 45) 26 significantly suppressed gastric emptying in rats.