By Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral Dizdaroglu, Ali Esat Karakaya (eds.)
Damage to DNA through either exogenous and endogenous resources is more and more considered as hugely vital within the initiation and development of melanoma and within the occurance of alternative pathological occasions. DNA harm brought on by reactive oxygen-derived species, also referred to as oxidative DNA harm, is such a lot the widespread style encountered by means of cardio cells. Mechanistic reports of carcinogenesis point out an enormous function of this sort of harm to DNA. there's additionally robust facts to help the function of oxidative DNA harm within the getting older method. DNA harm is adversarial in vivo by means of fix platforms. If no longer repaired, DNA harm could lead on to unsafe organic effects. as a result, the fix of DNA harm is considered one of many crucial occasions in all lifestyles types. in recent times the sphere of DNA fix has flourished as a result of new findings on DNA fix mechanisms and the molecular foundation of melanoma. a close wisdom of mechanisms of DNA harm and service, and the way person fix enzymes functionality could lead on to manipulation of DNA fix in cells and eventually to a rise of the resistence of human cells to DNA-damaging brokers. This quantity covers the newest devlopments during this examine box and includes contributions from scientists operating within the fields of biochemistry, molecular biology, enzymology, biomedical technological know-how, and radiation biology.
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Additional info for Advances in DNA Damage and Repair: Oxygen Radical Effects, Cellular Protection, and Biological Consequences
Am. Chem. Soc. 103: 3582-3584. D. M. Schaefer, Q. Liu, C. -C. Yin (1995). Supranutritional administration of vitamins E and C improves oxidative stability of beef, J. Nutr. 125: I 792S-1798S. Y. T Sugiura, Suzuki, 1. Kuwahara, and H. Tanaka (1982). On the mechanism of hydrogen peroxide-, superoxide-, and ultraviolet light-induced DNA cleavages of inactive bleomycin iron-(JII) complex, Biochem. Biophys. Res. Commun. 105: 1511-1518. D. S. Sigman (1986). Nuclease activity of I, I O-phenanthroline-copper ion, Acc.
52 Yes Yes No Yes Yes Yes Yes No Yes Yes Yes Yes Yes No Yes: l3-elimination Yes No mutator G/C to T/A Yes Yes nd Yes No Yes: l3-elimination Yes No nd Yes Yes nd Yes No Yes: l3-elimination Yes nd nd Yes Yes No Yes Yes nd Yes nd nd nd: not detennined. The data reported in this table are collected from, Auffret van der Kemp, et a!. (1996); Nash et a!. (1996); Thomas et a!. (1997); Girard et a!. (1997); Radicella et a!. (1997); Roldan-Arjona et a!. (1997); Arai et a!. (1997); Aburatani et a!. (1997); Rosenquist et a!.
65: 135. E. Yu, J. H. M. Wijsman, F. Hisama, R. Alisch, S. Mathews, 1. Nakura, T. Miki, S. M. Martin, 1. D. Schellenberg: Positional cloning of the Werner's syndrome gene (1996). Science 272:258. 4 EXCISION REPAIR OF 8-0XOGUANINE IN EUKARYOTES The Oggl Proteins Serge Boiteux and 1. Pablo Radicella Laboratoire de Radiobiologie du DNA UMR217 CNRS-CEA 60 Avenue du General Leclerc BP6, F-92265 Fontenay aux Roses, France 1. ABSTRACT 7,8-Dihydro-8-oxoguanine (8-0xoG) is a major mutagenic lesion produced on DNA by the endogenous oxidative stress.