Abeta Peptide and Alzheimer’s Disease: Celebrating a Century by David H. Small BSc, PhD (auth.), Colin J. Barrow BSc

By David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

Abeta Peptide and Alzheimer’s affliction summarizes present wisdom of beta-amyloid peptide (Aß) and its position because the significant wrongdoer in Alzheimer’s sickness (AD), proven via contemporary advances in genetics and mind biochemistry.

Written through leaders within the commercial and educational international focusing on this speedily relocating zone, the publication covers basic biochemical experiences at the Aß peptide, the genetic impression on Aß expression and processing, and numerous advert healing options that focus on Aß. even though in particular targeting Aß and advert, there's additionally a few dialogue at the similarity and modifications of this peptide and advert with different amyloidogenic illnesses, resembling prion sickness, Parkinson’s and Huntington’s.

This e-book will essentially be of curiosity to advert researchers and clinicians but in addition to researchers of different amyloid diseases.

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Biochemistry, 1999. 38(28):8972-8980. 220. , Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci, 1993. 13(4):1676-1687. 221. Lorenzo, A. , Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A, 1994. 91(25):12243-12247. 222. , Alzheimer’s disease amyloid-ß binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.

Neuroreport, 1998. 9(6):955959. 253. , Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease. Ann Neurol, 1994. 36(5):747-751. 254. , The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer’s disease. Neurobiol Aging, 2002. 23(3): 383-388. 255. , Evidence that amyloid beta-peptideinduced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death.

36:309-364. 298. , Iron accumulation in Alzheimer’s disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A, 1997. 94(18):9866-9868. 299. , Increased cerebral glucose-6phosphate dehydrogenase activity in Alzheimer’s disease may reflect oxidative stress. J Neurochem, 1986. 46(4):1042-1045. 300. , In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer’s disease: a central role for bound transition metals. J Neurochem, 2000. 74(1):270-279. 301.

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