36th Hemophilia Symposium Hamburg 2005 by H. Krebs, W. Schramm (auth.), Professor Dr.med. Inge

By H. Krebs, W. Schramm (auth.), Professor Dr.med. Inge Scharrer, Professor Dr.med. Wolfgang Schramm (eds.)

This publication includes the contribution to the thirty sixth Hemophilia Symposium, Hamburg 2005. the most themes are epidemiolgy, hemophilia treatment, orthopedic therapy in hemophiliacs, hemostaseologic prognosis and pediatric hemostaseology. the quantity is rounded off through various unfastened papers and posters on hemophilia, inhibitors in hemophilia and diagnostics.

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4. Krebs H, Domsch C, Adelhard K, Brackmann HH, Graw J, Oldenburg J, Schwaab R, Schramm W. The national GTH hemophilia registry as database within the scope of the German human genome project. Hämostaseologie. 2003; 23(1):18–23 II. Hemophilia Therapy – Management of Bleedings and Inhibitors Chairmen: W. Schramm (Munich) J. Oldenburg (Bonn) Regulation of Factor VIII Life-Cycle by Receptors from LDL Receptor Superfamily E. L. Saenko Summary The present review discusses the current concept of receptor-mediated clearance of coagulation factor VIII (FVIII) from the circulation in vivo, which is one of the mechanisms regulating FVIII level in plasma.

J Biol Chem 1997; 272: 18007–14. 4. Lenting PJ, van de Loo JW, Donath MJ, van Mourik JA, Mertens K. The sequence Glu1811Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX. J Biol Chem 1996; 271: 1935–40. 5. Fay PJ, Koshibu K. The A2 subunit of factor VIIIa modulates the active site of factor IXa. J Biol Chem 1998; 273: 19049–54. 6. Fay PJ, Scandella D. Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa.

Lighezan, F. Vladareanu, V. Uscatescu, C. Petrescu, C. Jinca, D. Mihailov, M. Ba˘ta˘neant, L. Pop, W. Schramm, and M. Serban Introduction Descriptive epidemiology can provide useful information concerning the quality of medical assistance in the case of genetic diseases, notorious for their equal and homogeneous distribution and independence from race, ethnicity and geographic belonging. Hemophilia is part of this group. ). A national registry centralizes this data for an entire country to avoid duplication of names.

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